Date: 16 October 2009
Name of applicant: Antisoma plc
Name of scheme: Antisoma Company Share Option Plan


+-------------------------------------------------------------------+
| Period of    | From:   | 14 Apr   | To:   | 15 Oct   |            |
| return       |         | 09       |       | 09       |            |
|------------------------------------------------------+------------|
| Number of securities issued/allotted under scheme(s) | 345,974    |
| during period (see LR3.5.7G): Company Share Option   |            |
| Plan                                                 |            |
|------------------------------------------------------+------------|
| Balance under scheme(s) not yet issued/allotted at   | 10,164,706 |
| end of period:                                       |            |
+-------------------------------------------------------------------+


In the period from 13 Oct 08 to 15 Oct 09, 870,539 shares have been
issued under the Antisoma Executive Incentive Plan. An application
for a blocklisting for 10,870,539 shares to cover the Antisoma
Executive Incentive Plan, the Antisoma Deferred Share Bonus Plan and
the 2008 Antisoma plc Company Share Option Plan has been made to the
UK Listing Authority and the London Stock Exchange.

All shares are Ordinary shares of 1p each

The total number of ordinary shares in the Company in issue and
admitted to the Official List is 615,354,790.

Enquiries:
Daniel Elger, VP, Marketing and Communications
Antisoma plc
+44 (0)20 3249 2222

Background on Antisoma
Antisoma is a London Stock Exchange-listed biopharmaceutical company
that develops novel products for the treatment of cancer. The Company
has operations in the UK and the US. Please visit www.antisoma.com
for further information about Antisoma.

---END OF MESSAGE---




This announcement was originally distributed by Hugin. The issuer is 
solely responsible for the content of this announcement.