TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARES

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

BIOFUTURES INTERNATIONAL PLC

2 Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

Other (please specify):

AMENDMENT TO THE FSA'S DISCLOSURE AND TRANSPARENCY RULES

 tick

3. Full name of person(s) subject to the notification obligation:

RELIGARE HICHENS, HARRISON PLC

4. Full name of shareholder(s) (if different from 3.):

5. Date of the transaction and date on which the threshold is crossed or reached:

1 JUNE 2009

6. Date on which issuer notified:

1 JUNE 2009

7. Threshold(s) that is/are crossed or reached:

 8%

8. Notified details:

A: Voting rights attached to shares

Class/type of
shares

if possible using
the ISIN CODE

Situation previous
to the triggering
transaction

Resulting situation after the triggering transaction

Number
of
Shares

Number
of
Voting
Rights

Number
of shares

Number of voting
rights

% of voting rights

Direct

Direct

Indirect

Direct

Indirect

ORDINARY

GB00B12B4T47

 11,712,177

 11,712,177

 11,712,172

 11,712,177

 -

 7.75%

 -

B: Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financial
instrument

Expiration
date

Exercise/ 
Conversion 
Period

Number of voting
rights that may be
acquired if the
instrument is
exercised/ converted.

% of voting
rights

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financial
instrument

Exercise 
price

Expiration 
date

Exercise/
Conversion 
period

Number of voting 
rights instrument 
refers to

% of voting rights

OPTION TO SUBSCRIBE FOR NEW ORDINARY SHARES 

 4.875P

 31/08/2012

 29/08/2008 - 31/08/2012

 1,510,600

Nominal

Delta

 1.00%

Total (A+B+C)

Number of voting rights

Percentage of voting rights

 13,222,777

 8.75%

9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable:

ORDINARY SHARES HELD BY RELIGARE HICHENS, HARRISON PLC

OPTION TO SUBSCRIBE FOR NEW ORDINARY SHARES HELD BY BLOMFIELD CORPORATE FINANCE LIMITED, A WHOLLY-OWNED SUBSIDIARY OF RELIGARE HICHENS, HARRISON PLC

Proxy Voting:

10. Name of the proxy holder:

11. Number of voting rights proxy holder will cease to hold:

12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

14. Contact name:

 JOHN EDEN

15. Contact telephone number:

 020 7382 7790

For further information contact:

JULIE POMEROY, FINANCE DIRECTOR, BIOFUTURES INTERNATIONAL PLC - 07936 848343

DEREK CROWHURST, BLOMFIELD CORPORATE FINANCE LIMITED - 020 7489 4500

COLIN ROWBURY, RELIGARE HICHENS, HARRISON PLC - 020 7382 7771