Zentiva N.V. - Notification of Changes in Shareholders' Structure

Prague, London, October 1, 2008 - Zentiva N.V. ('Zentiva') announces that Belviport Trading Ltd. disclosed to the Dutch Authority for the Financial Markets (Autoriteit Financiële Markten, the 'AFM') that, as of September 24, 2008, Belviport Trading Ltd. held directly 3,838,000 shares of Zentiva, representing 10.06% of total capital interest and voting rights in Zentiva.

PPF Group N.V. and Generali PPF Holding B.V. acting in concert disclosed to the AFM that, as of September 23, 2008, held indirectly 8,234,301 shares of Zentiva, representing 21,59% of total capital interest and voting rights in Zentiva.

Under Dutch law, if any person or entity actively or passively, directly or indirectly, acquires or disposes of shares and/or voting rights relating to Zentiva and such person or entity knows or should reasonably know that the shares and/or voting rights that are at its disposal reach, exceed or fall below any of the thresholds of 5%, 10%, 15%, 20%, 25%, 30%, 40%, 50%, 60%, 75%, or 95%, that person or entity must promptly notify the same to the AFM. Notifications received by AFM are then published by AFM on its website at www.afm.nl (go to 'English', 'Public database', and 'search in registers' for Zentiva).

Based on publicly available information¹, Zentiva's current shareholders' structure is as follows:

  ¹ Please note that a shareholder's disclosure obligation only applies if one of the relevant thresholds is crossed. Movements in shareholding within the thresholds are not required to be disclosed. Publicly disclosed information relates only to a specific date and may no longer be completely accurate as of a later date. Zentiva's information about its shareholders' structure is based only on publicly disclosed information.